Assay Detail
Binding
CHEMBL641886
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Inhibitory concentration against rat brain acetylcholinesterase AChE
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.26 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128471 | — | — | 1 | 9.22 |
| CHEMBL340625 | — | — | 1 | 8.82 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 8.70 |
| CHEMBL440526 | — | — | 1 | 8.70 |
| CHEMBL128202 | — | — | 1 | 8.40 |
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 7.70 |
| CHEMBL128863 | — | — | 1 | 7.40 |
| CHEMBL130918 | — | — | 1 | 7.16 |
| CHEMBL131827 | — | — | 1 | - |
| CHEMBL128260 | — | — | 1 | - |
| CHEMBL337999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128471 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL340625 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL440526 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL128202 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL128863 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL130918 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL131827 | — | IC50 | = | 0.009 | nM | - |
| CHEMBL128260 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL337999 | — | IC50 | > | 100.0 | nM | - |