Assay Detail
Binding
CHEMBL641889
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Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing two heterocyclic head groups
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300883 | — | — | 1 | 8.00 |
| CHEMBL300913 | — | — | 1 | 7.22 |
| CHEMBL48164 | — | — | 1 | 7.22 |
| CHEMBL49265 | — | — | 1 | 7.05 |
| CHEMBL51643 | — | — | 1 | 7.00 |
| CHEMBL50171 | — | — | 1 | 6.72 |
| CHEMBL51282 | — | — | 1 | 6.43 |
| CHEMBL431940 | — | — | 1 | 6.35 |
| CHEMBL48383 | — | — | 1 | 6.16 |
| CHEMBL297241 | — | — | 1 | 6.10 |
| CHEMBL298651 | — | — | 1 | 6.03 |
| CHEMBL48500 | — | — | 1 | 5.61 |
| CHEMBL49855 | — | — | 1 | 5.52 |
| CHEMBL299178 | — | — | 1 | 5.52 |
| CHEMBL301495 | — | — | 1 | 5.46 |
| CHEMBL445610 | — | — | 1 | 5.41 |
| CHEMBL50471 | — | — | 1 | 5.41 |
| CHEMBL48271 | — | — | 1 | 5.41 |
| CHEMBL50381 | — | — | 1 | 5.26 |
| CHEMBL301924 | — | — | 1 | 5.26 |
| CHEMBL406757 | — | — | 1 | 5.18 |
| CHEMBL48840 | — | — | 1 | 5.14 |
| CHEMBL275305 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300883 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL300913 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL48164 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL49265 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL51643 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL50171 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL51282 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL431940 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL48383 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL297241 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL298651 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL48500 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL49855 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL299178 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL301495 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL445610 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL50471 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL48271 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL50381 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL301924 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL406757 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL48840 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL275305 | — | IC50 | = | 7960.0 | nM | 5.10 |