Assay Detail
Binding
CHEMBL641890
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Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.23 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | 2.0 | 1 | 6.00 |
| CHEMBL45913 | — | — | 1 | 5.82 |
| CHEMBL48034 | — | — | 1 | 5.80 |
| CHEMBL46017 | — | — | 1 | 5.69 |
| CHEMBL49001 | — | — | 1 | 5.67 |
| CHEMBL46174 | — | — | 1 | 5.59 |
| CHEMBL45964 | — | — | 1 | 5.56 |
| CHEMBL431934 | — | — | 1 | 5.55 |
| CHEMBL291197 | — | — | 1 | 5.52 |
| CHEMBL416998 | — | — | 1 | 5.51 |
| CHEMBL300518 | — | — | 1 | 5.48 |
| CHEMBL432696 | — | — | 1 | 5.46 |
| CHEMBL298199 | — | — | 1 | 5.42 |
| CHEMBL295286 | — | — | 1 | 5.38 |
| CHEMBL45740 | — | — | 1 | 5.36 |
| CHEMBL44610 | — | — | 1 | 5.36 |
| CHEMBL46387 | — | — | 1 | 5.35 |
| CHEMBL45184 | — | — | 1 | 5.34 |
| CHEMBL49957 | — | — | 1 | 5.33 |
| CHEMBL50554 | — | — | 1 | 5.32 |
| CHEMBL416816 | — | — | 1 | 5.27 |
| CHEMBL49398 | — | — | 1 | 5.26 |
| CHEMBL43712 | — | — | 1 | 5.26 |
| CHEMBL49367 | — | — | 1 | 5.22 |
| CHEMBL45915 | — | — | 1 | 5.18 |
| CHEMBL47863 | — | — | 1 | 5.16 |
| CHEMBL45484 | — | — | 1 | 5.15 |
| CHEMBL417187 | — | — | 1 | 5.08 |
| CHEMBL49215 | — | — | 1 | 5.03 |
| CHEMBL295251 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL45913 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL48034 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL46017 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL49001 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL46174 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL45964 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL431934 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL291197 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL416998 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL300518 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL432696 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL298199 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL295286 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL44610 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL45740 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL46387 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL45184 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL49957 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL50554 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL416816 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL49398 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL43712 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL49367 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL45915 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL47863 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL45484 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL417187 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL49215 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL295251 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL297676 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL46318 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL297991 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL48106 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL295608 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL295079 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL289648 | — | IC50 | = | 72500.0 | nM | 4.14 |