Assay Detail
Functional
CHEMBL641986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.78 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27155 | — | — | 1 | 7.30 |
| CHEMBL423239 | — | — | 1 | 6.96 |
| CHEMBL276830 | — | — | 1 | 6.89 |
| CHEMBL27047 | — | — | 1 | 6.89 |
| CHEMBL158507 | — | — | 1 | 6.52 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.26 |
| CHEMBL418333 | — | — | 1 | 6.15 |
| CHEMBL11033 | — | — | 1 | 6.05 |
| CHEMBL11054 | — | — | 1 | 6.00 |
| CHEMBL273671 | — | — | 1 | 6.00 |
| CHEMBL11120 | — | — | 1 | 5.77 |
| CHEMBL415248 | — | — | 1 | 5.77 |
| CHEMBL11048 | — | — | 1 | 5.60 |
| CHEMBL157655 | — | — | 1 | 5.57 |
| CHEMBL8488 | — | — | 1 | 5.20 |
| CHEMBL279688 | — | — | 1 | 5.16 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.85 |
| CHEMBL89062 | — | — | 1 | 4.85 |
| CHEMBL273953 | — | — | 1 | 4.82 |
| CHEMBL21053 | — | — | 1 | 4.57 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.30 |
| CHEMBL11146 | — | — | 1 | - |
| CHEMBL20613 | — | — | 1 | - |
| CHEMBL20402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27155 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL423239 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL276830 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL27047 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL158507 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL418333 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL11033 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL11054 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL273671 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL11120 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL415248 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL11048 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL157655 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL8488 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL279688 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL89062 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL273953 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL21053 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL113 | CAFFEINE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL11146 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL20613 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL20402 | — | Ki | > | 10000.0 | nM | - |