Assay Detail
Binding
CHEMBL641989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against adenosine A2 receptor of striatal membrane using [3H]CGS-21680 as a radioligand
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 4.79 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157655 | — | — | 1 | 5.62 |
| CHEMBL29518 | — | — | 1 | 5.50 |
| CHEMBL28194 | — | — | 1 | 5.41 |
| CHEMBL28980 | — | — | 1 | 5.25 |
| CHEMBL286976 | — | — | 1 | 5.10 |
| CHEMBL29461 | — | — | 1 | 4.93 |
| CHEMBL287180 | — | — | 1 | 4.92 |
| CHEMBL28075 | — | — | 1 | 4.92 |
| CHEMBL28879 | — | — | 1 | 4.89 |
| CHEMBL445847 | — | — | 1 | 4.80 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.78 |
| CHEMBL283412 | — | — | 1 | 4.67 |
| CHEMBL29272 | — | — | 1 | 4.67 |
| CHEMBL283024 | — | — | 1 | 4.64 |
| CHEMBL282310 | — | — | 1 | 4.36 |
| CHEMBL28298 | — | — | 1 | 4.23 |
| CHEMBL283454 | — | — | 1 | 4.16 |
| CHEMBL288786 | — | — | 1 | 4.09 |
| CHEMBL279898 | ENPROFYLLINE | 2.0 | 1 | 4.04 |
| CHEMBL283020 | — | — | 1 | - |
| CHEMBL281972 | — | — | 1 | - |
| CHEMBL28683 | — | — | 1 | - |
| CHEMBL32184 | — | — | 1 | - |
| CHEMBL286741 | — | — | 1 | - |
| CHEMBL31838 | — | — | 1 | - |
| CHEMBL29052 | — | — | 1 | - |
| CHEMBL31859 | — | — | 1 | - |
| CHEMBL29209 | — | — | 1 | - |
| CHEMBL27967 | — | — | 1 | - |
| CHEMBL28419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157655 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL29518 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL28194 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL28980 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL286976 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL29461 | — | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL287180 | — | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL28075 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL28879 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL445847 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 16600.0 | nM | 4.78 |
| CHEMBL283412 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL29272 | — | Ki | = | 21600.0 | nM | 4.67 |
| CHEMBL283024 | — | Ki | = | 22900.0 | nM | 4.64 |
| CHEMBL282310 | — | Ki | = | 43800.0 | nM | 4.36 |
| CHEMBL28298 | — | Ki | = | 58700.0 | nM | 4.23 |
| CHEMBL283454 | — | Ki | = | 68700.0 | nM | 4.16 |
| CHEMBL288786 | — | Ki | = | 81500.0 | nM | 4.09 |
| CHEMBL279898 | ENPROFYLLINE | Ki | = | 90600.0 | nM | 4.04 |
| CHEMBL282160 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL28684 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL27970 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL28295 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL28300 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL28603 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL32241 | — | Ki | = | 162000.0 | nM | - |
| CHEMBL27915 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL27969 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL282394 | — | Ki | = | 144000.0 | nM | - |
| CHEMBL28419 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL27967 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL29209 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL31859 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL29052 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL31838 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL286741 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL32184 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL28683 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL281972 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL283020 | — | Ki | > | 200000.0 | nM | - |