Assay Detail
Functional
CHEMBL641992
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Inhibition of 2-CADO-stimulated adenylate cyclase at Adenosine A2 receptor in guinea pig cerebral cortical slices
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.40 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26350 | — | — | 1 | 5.77 |
| CHEMBL157655 | — | — | 1 | 5.57 |
| CHEMBL416013 | — | — | 1 | 5.52 |
| CHEMBL286785 | — | — | 1 | 5.30 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26350 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL157655 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL416013 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL286785 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 14000.0 | nM | 4.85 |