Assay Detail
Binding
CHEMBL642017
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Displacement of specific [125I]AB-MECA binding at rat Adenosine A3 receptor stably expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.23 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111545 | — | — | 1 | 6.95 |
| CHEMBL162630 | — | — | 1 | 6.81 |
| CHEMBL111086 | — | — | 1 | 6.74 |
| CHEMBL321845 | — | — | 1 | 6.39 |
| CHEMBL2112931 | — | — | 1 | 6.30 |
| CHEMBL422184 | — | — | 1 | 6.29 |
| CHEMBL164321 | — | — | 1 | 6.22 |
| CHEMBL164210 | — | — | 1 | 6.05 |
| CHEMBL89852 | — | — | 1 | 5.85 |
| CHEMBL348766 | — | — | 1 | 5.59 |
| CHEMBL440720 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111545 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL162630 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL111086 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL321845 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL2112931 | — | Ki | = | 495.0 | nM | 6.30 |
| CHEMBL422184 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL164321 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL164210 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL89852 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL348766 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL440720 | — | Ki | = | 4260.0 | nM | 5.37 |