Assay Detail
Binding
CHEMBL642018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Testis |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.57 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66393 | — | — | 1 | 7.99 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.58 |
| CHEMBL284969 | — | — | 1 | 7.52 |
| CHEMBL119709 | IB-MECA | — | 1 | 7.52 |
| CHEMBL464859 | NECA | — | 1 | 7.31 |
| CHEMBL139000 | (R)-PIA | — | 1 | 7.28 |
| CHEMBL400189 | — | — | 1 | 6.68 |
| CHEMBL420705 | (S)-PIA | — | 1 | 6.62 |
| CHEMBL605034 | — | — | 1 | 6.50 |
| CHEMBL2113418 | — | — | 1 | 6.26 |
| CHEMBL2113388 | — | — | 1 | 5.97 |
| CHEMBL285819 | — | — | 1 | 5.50 |
| CHEMBL444550 | — | — | 1 | 5.49 |
| CHEMBL251997 | — | — | 1 | 5.30 |
| CHEMBL603977 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66393 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL284969 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL119709 | IB-MECA | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL464859 | NECA | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL139000 | (R)-PIA | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL400189 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL420705 | (S)-PIA | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL605034 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL2113418 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2113388 | — | Ki | = | 1082.0 | nM | 5.97 |
| CHEMBL285819 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL444550 | — | Ki | = | 3250.0 | nM | 5.49 |
| CHEMBL251997 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL603977 | — | Ki | = | 10000.0 | nM | 5.00 |