Assay Detail
Binding
CHEMBL642030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1b expressed in LTK cell
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Alpha-1B adrenergic receptor (CHEMBL3122) ↗| Type | SINGLE PROTEIN |
| Organism | Mesocricetus auratus |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.68 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 9.70 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 9.16 |
| CHEMBL295741 | — | — | 1 | 8.38 |
| CHEMBL290387 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL611 | TERAZOSIN | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL295741 | — | Ki | = | 4.15 | nM | 8.38 |
| CHEMBL290387 | — | Ki | = | 35.1 | nM | 7.46 |