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Assay Detail

CHEMBL642037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FG binding to alpha IIb beta-3 integrin
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Integrin alpha-IIb/beta-3 (CHEMBL2093869)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
Weller T, Alig L, Beresini M, Blackburn B, Bunting S, Hadváry P, Müller MH, Knopp D, Levet-Trafit B, Lipari MT, Modi NB, Müller M, Refino CJ, Schmitt M, Schönholzer P, Weiss S, Steiner B.
J Med Chem (1996) 39 : 3139 -3147
PubMed 8759635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.55 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290497 1 9.40
CHEMBL108111 LAMIFIBAN 2.0 1 8.85
CHEMBL65267 RO-44-3888 -1.0 1 8.72
CHEMBL107279 1 7.29
CHEMBL106349 1 7.05
CHEMBL320317 1 6.79
CHEMBL107471 1 6.23
CHEMBL106059 1 6.05
CHEMBL106947 1 -
CHEMBL325367 1 -
CHEMBL325139 1 -
CHEMBL106838 1 -
CHEMBL106500 1 -
CHEMBL107130 1 -
CHEMBL107449 1 -
CHEMBL104518 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290497 IC50 = 0.4 nM 9.40
CHEMBL108111 LAMIFIBAN IC50 = 1.4 nM 8.85
CHEMBL65267 RO-44-3888 IC50 = 1.9 nM 8.72
CHEMBL107279 IC50 = 51.0 nM 7.29
CHEMBL106349 IC50 = 90.0 nM 7.05
CHEMBL320317 IC50 = 163.0 nM 6.79
CHEMBL107471 IC50 = 594.0 nM 6.23
CHEMBL106059 IC50 = 900.0 nM 6.05
CHEMBL106947 IC50 > 10000.0 nM -
CHEMBL325367 IC50 > 10000.0 nM -
CHEMBL325139 IC50 > 10000.0 nM -
CHEMBL106838 IC50 > 8000.0 nM -
CHEMBL106500 IC50 > 10000.0 nM -
CHEMBL107130 IC50 > 10000.0 nM -
CHEMBL107449 IC50 > 10000.0 nM -
CHEMBL104518 IC50 > 10000.0 nM -