Compound Detail
CHEMBL320317
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Basic Information
| ChEMBL ID | CHEMBL320317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UEEVNDRFIJHHGB-ZDUSSCGKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
404.5
MW (Da)
0.66
ALogP
6
HBA
3
HBD
134.8
PSA (Ų)
0.33
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Integrin alpha-IIb/beta-3 CHEMBL2093869 | IC50 | 6.79 | 6.79 | 163.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Integrin alpha-IIb/beta-3 | IC50 | = | 163.0 | nM | 6.79 | Inhibition of FG binding to alpha IIb beta-3 integrin | 8759635 |
| Homo sapiens | IC50 | = | 500.0 | nM | 6.3 | Inhibition of platelet aggregation in human platelet rich plasma(h-PRP) induced ... | 8759635 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8759635 | 10.1021/jm9509298 | Homo sapiens | 2 |
| 8759635 | 10.1021/jm9509298 | Integrin alpha-IIb/beta-3 | 1 |
Data from ChEMBL 36 via Core Engine