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Assay Detail

CHEMBL642093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.
Parikh V, Welch WM, Schmidt AW.
Bioorg Med Chem Lett (2003) 13 : 269 -271
PubMed 12482437 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.78 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94017 1 7.36
CHEMBL90118 1 7.16
CHEMBL540821 1 7.05
CHEMBL544315 1 7.04
CHEMBL329548 1 6.99
CHEMBL327906 1 6.88
CHEMBL90752 1 6.78
CHEMBL92856 1 6.68
CHEMBL92221 1 6.68
CHEMBL90150 1 6.59
CHEMBL327654 1 6.59
CHEMBL316283 1 6.58
CHEMBL90538 1 6.56
CHEMBL94056 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94017 Ki = 43.65 nM 7.36
CHEMBL90118 Ki = 69.18 nM 7.16
CHEMBL540821 Ki = 89.13 nM 7.05
CHEMBL544315 Ki = 91.2 nM 7.04
CHEMBL329548 Ki = 102.33 nM 6.99
CHEMBL327906 Ki = 131.83 nM 6.88
CHEMBL90752 Ki = 165.96 nM 6.78
CHEMBL92856 Ki = 208.93 nM 6.68
CHEMBL92221 Ki = 208.93 nM 6.68
CHEMBL90150 Ki = 257.04 nM 6.59
CHEMBL327654 Ki = 257.04 nM 6.59
CHEMBL316283 Ki = 263.03 nM 6.58
CHEMBL90538 Ki = 275.42 nM 6.56
CHEMBL94056 Ki = 1202.26 nM 5.92