Assay Detail
Binding
CHEMBL642100
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Displacement of [3H]prazosin from rat brain Alpha-1 adrenergic receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.45 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.13 |
| CHEMBL35057 | TIOSPIRONE | 2.0 | 1 | 8.83 |
| CHEMBL37633 | — | — | 1 | 8.68 |
| CHEMBL284847 | — | — | 1 | 8.63 |
| CHEMBL35743 | — | — | 1 | 8.52 |
| CHEMBL35085 | — | — | 1 | 8.38 |
| CHEMBL287605 | — | — | 1 | 8.35 |
| CHEMBL35565 | — | — | 1 | 8.29 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.25 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.20 |
| CHEMBL35040 | — | — | 1 | 8.19 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL35057 | TIOSPIRONE | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL37633 | — | Ki | = | 2.089 | nM | 8.68 |
| CHEMBL284847 | — | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL35743 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL35085 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL287605 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL35565 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL42 | CLOZAPINE | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL35040 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 10.47 | nM | 7.98 |