Assay Detail
Binding
CHEMBL642124
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Binding affinity towards Adenosine A2A receptor of bovine striatal membrane using [3H]-CGS- at 20 uM
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.19 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274274 | — | — | 1 | 8.19 |
| CHEMBL416537 | — | — | 1 | 7.84 |
| CHEMBL416354 | — | — | 1 | 7.73 |
| CHEMBL278197 | — | — | 1 | 7.31 |
| CHEMBL279870 | — | — | 1 | 7.18 |
| CHEMBL16643 | — | — | 1 | 7.14 |
| CHEMBL273578 | — | — | 1 | 7.07 |
| CHEMBL16416 | — | — | 1 | 6.42 |
| CHEMBL274267 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274274 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL416537 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL416354 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL278197 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL279870 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL16643 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL273578 | — | Ki | = | 85.8 | nM | 7.07 |
| CHEMBL16416 | — | Ki | = | 376.0 | nM | 6.42 |
| CHEMBL274267 | — | Ki | = | 1370.0 | nM | 5.86 |