Assay Detail
Binding
CHEMBL642192
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Displacement of [3H]R-PIA from Adenosine A1 receptor of rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.79 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112436 | — | — | 1 | 5.17 |
| CHEMBL2111655 | — | — | 1 | 4.83 |
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 1 | 4.38 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112436 | — | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL2111655 | — | Ki | = | 14800.0 | nM | 4.83 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 41300.0 | nM | 4.38 |
| CHEMBL405355 | NIGULDIPINE | Ki | > | 100000.0 | nM | - |