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Assay Detail

CHEMBL642224

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human recombinant adenosine kinase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine kinase (CHEMBL3589)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides.
Ugarkar BG, Castellino AJ, DaRe JS, Ramirez-Weinhouse M, Kopcho JJ, Rosengren S, Erion MD.
J Med Chem (2003) 46 : 4750 -4760
PubMed 14561094 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.21 9.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL343247 1 9.33
CHEMBL436598 1 9.10
CHEMBL344529 1 8.82
CHEMBL141327 1 8.55
CHEMBL356141 1 8.40
CHEMBL66277 1 8.30
CHEMBL358584 1 7.82
CHEMBL144936 1 7.80
CHEMBL99203 IODOTUBERCIDIN 1 7.58
CHEMBL422122 1 7.44
CHEMBL356758 1 7.38
CHEMBL356952 1 7.17
CHEMBL342959 1 6.77
CHEMBL141606 1 6.55
CHEMBL145388 1 6.40
CHEMBL145188 1 6.00
CHEMBL142234 1 5.70
CHEMBL356312 1 5.00
CHEMBL145092 1 5.00
CHEMBL143644 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL343247 IC50 = 0.47 nM 9.33
CHEMBL436598 IC50 = 0.8 nM 9.10
CHEMBL344529 IC50 = 1.5 nM 8.82
CHEMBL141327 IC50 = 2.8 nM 8.55
CHEMBL356141 IC50 = 4.0 nM 8.40
CHEMBL66277 IC50 = 5.0 nM 8.30
CHEMBL358584 IC50 = 15.0 nM 7.82
CHEMBL144936 IC50 = 16.0 nM 7.80
CHEMBL99203 IODOTUBERCIDIN IC50 = 26.0 nM 7.58
CHEMBL422122 IC50 = 36.0 nM 7.44
CHEMBL356758 IC50 = 42.0 nM 7.38
CHEMBL356952 IC50 = 68.0 nM 7.17
CHEMBL342959 IC50 = 170.0 nM 6.77
CHEMBL141606 IC50 = 280.0 nM 6.55
CHEMBL145388 IC50 = 400.0 nM 6.40
CHEMBL145188 IC50 = 1000.0 nM 6.00
CHEMBL142234 IC50 = 2000.0 nM 5.70
CHEMBL356312 IC50 = 10000.0 nM 5.00
CHEMBL145092 IC50 = 10000.0 nM 5.00
CHEMBL143644 IC50 = 10000.0 nM 5.00