Assay Detail
Binding
CHEMBL642226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of adenosine kinase activity in IMR-32 human neuroblastoma cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IMR-32 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.49 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150478 | — | — | 1 | 7.60 |
| CHEMBL348712 | — | — | 1 | 7.31 |
| CHEMBL151448 | — | — | 1 | 7.28 |
| CHEMBL422489 | — | — | 1 | 6.89 |
| CHEMBL358714 | — | — | 1 | 6.89 |
| CHEMBL151812 | — | — | 1 | 6.81 |
| CHEMBL346622 | — | — | 1 | 6.79 |
| CHEMBL151214 | — | — | 1 | 6.71 |
| CHEMBL356256 | — | — | 1 | 6.60 |
| CHEMBL150370 | — | — | 1 | 6.54 |
| CHEMBL342310 | — | — | 1 | 6.46 |
| CHEMBL356896 | — | — | 1 | 6.43 |
| CHEMBL439635 | — | — | 1 | 6.35 |
| CHEMBL68492 | — | — | 1 | 6.33 |
| CHEMBL265251 | — | — | 1 | 6.20 |
| CHEMBL435646 | — | — | 1 | 6.20 |
| CHEMBL150978 | — | — | 1 | 5.82 |
| CHEMBL66338 | — | — | 1 | 5.44 |
| CHEMBL151553 | — | — | 1 | 4.66 |
| CHEMBL147390 | — | — | 1 | - |
| CHEMBL151079 | — | — | 1 | - |
| CHEMBL147356 | — | — | 1 | - |
| CHEMBL303499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150478 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL348712 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL151448 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL422489 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL358714 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL151812 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL346622 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL151214 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL356256 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL150370 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL342310 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL356896 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL439635 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL68492 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL265251 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL435646 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL150978 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL66338 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL151553 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL147390 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151079 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL147356 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL303499 | — | IC50 | > | 10000.0 | nM | - |