Assay Detail
Binding
CHEMBL642272
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Inhibitory activity against Activated protein C
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.65 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322165 | — | — | 1 | 4.99 |
| CHEMBL322901 | — | — | 1 | 4.92 |
| CHEMBL107627 | — | — | 1 | 4.87 |
| CHEMBL107392 | — | — | 1 | 4.82 |
| CHEMBL319035 | — | — | 1 | 4.48 |
| CHEMBL107282 | — | — | 1 | 4.41 |
| CHEMBL107911 | — | — | 1 | 4.03 |
| CHEMBL107743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322165 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL322901 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL107627 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL107392 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL319035 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL107282 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL107911 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL107743 | — | Ki | = | 180000.0 | nM | - |