Assay Detail
Binding
CHEMBL642284
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Inhibitory activity against activated protein C (aPC)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352039 | — | — | 1 | 5.22 |
| CHEMBL355376 | — | — | 1 | - |
| CHEMBL162461 | — | — | 1 | - |
| CHEMBL423810 | — | — | 1 | - |
| CHEMBL163174 | — | — | 1 | - |
| CHEMBL159695 | — | — | 1 | - |
| CHEMBL350587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352039 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL355376 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL162461 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL423810 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL163174 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL159695 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL350587 | — | IC50 | = | 170000.0 | nM | - |