Assay Detail
Binding
CHEMBL642295
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Inhibitory activity against Acetylcholinesterase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.33 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140020 | — | — | 1 | 8.10 |
| CHEMBL539109 | — | — | 1 | 7.47 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.24 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.12 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.04 |
| CHEMBL609150 | — | — | 1 | 6.96 |
| CHEMBL609671 | — | — | 1 | 6.82 |
| CHEMBL54727 | — | — | 1 | 6.46 |
| CHEMBL612100 | — | — | 1 | 6.34 |
| CHEMBL60745 | EDROPHONIUM BROMIDE | — | 1 | 6.11 |
| CHEMBL609149 | — | — | 1 | 6.01 |
| CHEMBL609668 | — | — | 1 | 5.77 |
| CHEMBL609409 | — | — | 1 | 5.75 |
| CHEMBL612099 | — | — | 1 | 5.20 |
| CHEMBL609672 | — | — | 1 | 4.46 |
| CHEMBL612098 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140020 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL539109 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL95 | TACRINE | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL609150 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL609671 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL54727 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL612100 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL60745 | EDROPHONIUM BROMIDE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL609149 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL609668 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL609409 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL612099 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL609672 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL612098 | — | IC50 | = | 40000.0 | nM | 4.40 |