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Assay Detail

CHEMBL642296

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Binding
Inhibitory activity against Acetylcholinesterase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.
Obata R, Sunazuka T, Otoguro K, Tomoda H, Harigaya Y, Omura S.
Bioorg Med Chem Lett (2000) 10 : 1315 -1316
PubMed 10890154 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.64 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283509 1 9.00
CHEMBL24686 TERRITREM B 1 8.10
CHEMBL278342 1 7.58
CHEMBL24519 1 5.10
CHEMBL25629 1 4.46
CHEMBL24844 1 4.24
CHEMBL24416 1 4.16
CHEMBL25149 1 4.10
CHEMBL277665 1 4.00
CHEMBL24457 1 -
CHEMBL25524 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283509 IC50 = 1.0 nM 9.00
CHEMBL24686 TERRITREM B IC50 = 8.0 nM 8.10
CHEMBL278342 IC50 = 26.0 nM 7.58
CHEMBL24519 IC50 = 7900.0 nM 5.10
CHEMBL25629 IC50 = 35000.0 nM 4.46
CHEMBL24844 IC50 = 58000.0 nM 4.24
CHEMBL24416 IC50 = 70000.0 nM 4.16
CHEMBL25149 IC50 = 80000.0 nM 4.10
CHEMBL277665 IC50 = 99000.0 nM 4.00
CHEMBL24457 IC50 > 93000.0 nM -
CHEMBL25524 IC50 = 101000.0 nM -