Assay Detail
Binding
CHEMBL642300
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Binding affinity for Adenosine A1 receptor by inhibition of [3H]PIA binding to whole rat brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrazolo[3,4-d]pyrimidines; adenosine receptor selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.95 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310796 | — | — | 1 | 7.92 |
| CHEMBL80282 | — | — | 1 | 7.54 |
| CHEMBL78636 | — | — | 1 | 6.64 |
| CHEMBL79201 | — | — | 1 | 6.37 |
| CHEMBL79223 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310796 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL80282 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL78636 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL79201 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL79223 | — | Ki | = | 551.0 | nM | 6.26 |