Assay Detail
Binding
CHEMBL642334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 5.79 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158507 | — | — | 1 | 8.00 |
| CHEMBL274855 | — | — | 1 | 7.70 |
| CHEMBL22042 | — | — | 1 | 7.07 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 6.85 |
| CHEMBL106265 | 8-CYCLOPENTYLTHEOPHYLLINE | — | 1 | 6.85 |
| CHEMBL321505 | — | — | 1 | 6.82 |
| CHEMBL160369 | — | — | 1 | 6.72 |
| CHEMBL281811 | — | — | 1 | 6.72 |
| CHEMBL22099 | — | — | 1 | 6.66 |
| CHEMBL423239 | — | — | 1 | 6.50 |
| CHEMBL279688 | — | — | 1 | 6.28 |
| CHEMBL9069 | — | — | 1 | 6.07 |
| CHEMBL21449 | — | — | 1 | 5.96 |
| CHEMBL11048 | — | — | 1 | 5.82 |
| CHEMBL1250 | 1-METHYLXANTHINE | — | 1 | 5.72 |
| CHEMBL418333 | — | — | 1 | 5.72 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 5.72 |
| CHEMBL20483 | — | — | 1 | 5.68 |
| CHEMBL20402 | — | — | 1 | 5.64 |
| CHEMBL418375 | — | — | 1 | 5.62 |
| CHEMBL22178 | — | — | 1 | 5.62 |
| CHEMBL281633 | — | — | 1 | 5.57 |
| CHEMBL278332 | — | — | 1 | 5.55 |
| CHEMBL8488 | — | — | 1 | 5.26 |
| CHEMBL20613 | — | — | 1 | 5.19 |
| CHEMBL157655 | — | — | 1 | 5.13 |
| CHEMBL20806 | — | — | 1 | 4.96 |
| CHEMBL278104 | — | — | 1 | 4.89 |
| CHEMBL280367 | — | — | 1 | 4.85 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158507 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL274855 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL22042 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL106265 | 8-CYCLOPENTYLTHEOPHYLLINE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL321505 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL160369 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL281811 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL22099 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL423239 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL279688 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL9069 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL21449 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL11048 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL1250 | 1-METHYLXANTHINE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL418333 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL20483 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL20402 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL418375 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL22178 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL281633 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL278332 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL8488 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL20613 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL157655 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL20806 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL278104 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL21053 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL280367 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL21172 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL21554 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL113 | CAFFEINE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL20993 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL279898 | ENPROFYLLINE | Ki | = | 130000.0 | nM | - |
| CHEMBL20844 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL619 | 3-METHYLXANTHINE | Ki | = | 240000.0 | nM | - |