Assay Detail
Binding
CHEMBL642335
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Inhibition of NECA binding to adenosine A2 receptor mediates reduced adenylate cyclase activity in human platelets
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355370 | — | — | 1 | 6.16 |
| CHEMBL27041 | — | — | 1 | 6.10 |
| CHEMBL349519 | — | — | 1 | 6.00 |
| CHEMBL162814 | — | — | 1 | 5.75 |
| CHEMBL162658 | — | — | 1 | 5.68 |
| CHEMBL162558 | — | — | 1 | 5.28 |
| CHEMBL161933 | — | — | 1 | 5.28 |
| CHEMBL164623 | — | — | 1 | 5.27 |
| CHEMBL162986 | — | — | 1 | 4.94 |
| CHEMBL351481 | — | — | 1 | 4.94 |
| CHEMBL353115 | — | — | 1 | 4.91 |
| CHEMBL162702 | — | — | 1 | 4.70 |
| CHEMBL163574 | — | — | 1 | 4.64 |
| CHEMBL161934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355370 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL27041 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL349519 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL162814 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL162658 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL162558 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL161933 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL164623 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL162986 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL351481 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL353115 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL162702 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL163574 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL161934 | — | Ki | > | 100000.0 | nM | - |