Assay Detail
Binding
CHEMBL642476
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Evaluated for binding affinity against Adenosine A1 receptor
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.19 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.49 |
| CHEMBL45891 | — | — | 1 | 9.07 |
| CHEMBL607777 | — | — | 1 | 9.00 |
| CHEMBL611903 | — | — | 2 | 8.92 |
| CHEMBL610427 | — | — | 1 | 8.70 |
| CHEMBL2113423 | — | — | 1 | 8.68 |
| CHEMBL612218 | — | — | 1 | 8.66 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.48 |
| CHEMBL608952 | — | — | 1 | 8.40 |
| CHEMBL1093910 | — | — | 2 | 8.34 |
| CHEMBL605042 | — | — | 1 | 8.31 |
| CHEMBL607776 | — | — | 1 | 8.05 |
| CHEMBL612221 | — | — | 1 | 7.57 |
| CHEMBL604407 | — | — | 1 | 7.40 |
| CHEMBL608355 | — | — | 1 | 7.33 |
| CHEMBL604860 | — | — | 1 | 7.07 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL45891 | — | IC50 | = | 0.8511 | nM | 9.07 |
| CHEMBL607777 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL611903 | — | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL610427 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL2113423 | — | IC50 | = | 2.089 | nM | 8.68 |
| CHEMBL612218 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL262083 | N6-PHENYLADENOSINE | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL608952 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL1093910 | — | IC50 | = | 4.571 | nM | 8.34 |
| CHEMBL605042 | — | IC50 | = | 4.898 | nM | 8.31 |
| CHEMBL607776 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL1093910 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL612221 | — | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL604407 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL608355 | — | IC50 | = | 46.77 | nM | 7.33 |
| CHEMBL611903 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL604860 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL388757 | N6-BENZYLADENOSINE | IC50 | = | 125.89 | nM | 6.90 |