Assay Detail
Binding
CHEMBL642728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Activin like receptor kinase 5, TGF beta type I receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.00 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440084 | SB-431542 | — | 1 | 7.03 |
| CHEMBL6250 | — | — | 1 | 6.77 |
| CHEMBL267228 | — | — | 1 | 6.58 |
| CHEMBL6252 | — | — | 1 | 6.40 |
| CHEMBL268889 | — | — | 1 | 6.34 |
| CHEMBL269339 | — | — | 1 | 5.82 |
| CHEMBL266706 | — | — | 1 | 5.80 |
| CHEMBL269341 | — | — | 1 | 5.53 |
| CHEMBL6204 | — | — | 1 | 5.29 |
| CHEMBL6304 | — | — | 1 | 5.24 |
| CHEMBL10 | SB-203580 | — | 1 | 5.22 |
| CHEMBL266707 | — | — | 1 | - |
| CHEMBL6294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440084 | SB-431542 | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL6250 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL267228 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL6252 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL268889 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL269339 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL266706 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL269341 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL6204 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL6304 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL10 | SB-203580 | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL266707 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL6294 | — | IC50 | > | 50000.0 | nM | - |