Compound Detail
CHEMBL6304
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Basic Information
| ChEMBL ID | CHEMBL6304 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QRDCJBZLKGOQNO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
279.3
MW (Da)
3.70
ALogP
3
HBA
0
HBD
30.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 5.24 | 5.24 | 5800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | IC50 | = | 5800.0 | nM | 5.24 | Inhibition of Activin like receptor kinase 5, TGF beta type I receptor | 11855979 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11855979 | 10.1021/jm010493y | TGF-beta receptor type-1 | 1 |
| 11855979 | 10.1021/jm010493y | MAP kinase p38 | 1 |
Data from ChEMBL 36 via Core Engine