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Assay Detail

CHEMBL642745

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Binding
Inhibition of acetylcholinesterase (AChE) activity
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL3199)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase.
DeBernardis JF, Gifford P, Rizk M, Ertel R, Abraham DJ, Siuda JF.
J Med Chem (1988) 31 : 117 -121
PubMed 3336013 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.66 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279876 1 6.82
CHEMBL18903 1 5.41
CHEMBL283112 1 5.00
CHEMBL19537 1 4.76
CHEMBL18432 1 4.57
CHEMBL19470 1 4.52
CHEMBL282920 1 4.52
CHEMBL428683 1 4.51
CHEMBL19487 1 4.50
CHEMBL278742 1 4.44
CHEMBL282917 1 4.40
CHEMBL19325 1 4.35
CHEMBL552981 1 4.29
CHEMBL19318 1 4.19
CHEMBL19486 1 4.17
CHEMBL278327 1 4.10
CHEMBL19388 1 -
CHEMBL278309 1 -
CHEMBL18766 1 -
CHEMBL18920 1 -
CHEMBL279153 1 -
CHEMBL19337 1 -
CHEMBL538103 1 -
CHEMBL18863 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279876 IC50 = 151.0 nM 6.82
CHEMBL18903 IC50 = 3900.0 nM 5.41
CHEMBL283112 IC50 = 10000.0 nM 5.00
CHEMBL19537 IC50 = 17500.0 nM 4.76
CHEMBL18432 IC50 = 27000.0 nM 4.57
CHEMBL19470 IC50 = 30000.0 nM 4.52
CHEMBL282920 IC50 = 30000.0 nM 4.52
CHEMBL428683 IC50 = 31000.0 nM 4.51
CHEMBL19487 IC50 = 32000.0 nM 4.50
CHEMBL278742 IC50 = 36000.0 nM 4.44
CHEMBL282917 IC50 = 40000.0 nM 4.40
CHEMBL19325 IC50 = 45000.0 nM 4.35
CHEMBL552981 IC50 = 51000.0 nM 4.29
CHEMBL19318 IC50 = 64000.0 nM 4.19
CHEMBL19486 IC50 = 68000.0 nM 4.17
CHEMBL278327 IC50 = 80000.0 nM 4.10
CHEMBL19388 IC50 = 1000000.0 nM -
CHEMBL278309 IC50 = 500000.0 nM -
CHEMBL18766 IC50 = 220000.0 nM -
CHEMBL18920 IC50 = 130000.0 nM -
CHEMBL279153 IC50 = 140000.0 nM -
CHEMBL19337 IC50 = 750000.0 nM -
CHEMBL538103 IC50 = 120000.0 nM -
CHEMBL18863 IC50 = 350000.0 nM -