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Assay Detail

CHEMBL642844

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against acetylcholinetransferase (AChE) enzyme
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL3199)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.
Gray AP, Platz RD, Henderson TR, Chang TC, Takahashi K, Dretchen KL.
J Med Chem (1988) 31 : 807 -814
PubMed 3351860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 4.42 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL166410 1 4.70
CHEMBL170902 1 4.62
CHEMBL168155 1 4.50
CHEMBL353720 1 4.50
CHEMBL166752 1 4.48
CHEMBL262139 1 4.37
CHEMBL165808 1 4.28
CHEMBL354870 1 4.19
CHEMBL166693 1 4.16
CHEMBL167979 1 -
CHEMBL167967 1 -
CHEMBL441492 1 -
CHEMBL165809 1 -
CHEMBL166791 1 -
CHEMBL166811 1 -
CHEMBL354158 1 -
CHEMBL553877 1 -
CHEMBL433527 1 -
CHEMBL167408 1 -
CHEMBL168464 1 -
CHEMBL166723 1 -
CHEMBL353761 1 -
CHEMBL19486 1 -
CHEMBL354726 1 -
CHEMBL354866 1 -
CHEMBL168580 1 -
CHEMBL168468 1 -
CHEMBL354506 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL166410 IC50 = 20000.0 nM 4.70
CHEMBL170902 IC50 = 24000.0 nM 4.62
CHEMBL168155 IC50 = 32000.0 nM 4.50
CHEMBL353720 IC50 = 32000.0 nM 4.50
CHEMBL166752 IC50 = 33000.0 nM 4.48
CHEMBL262139 IC50 = 43000.0 nM 4.37
CHEMBL165808 IC50 = 52000.0 nM 4.28
CHEMBL354870 IC50 = 64000.0 nM 4.19
CHEMBL166693 IC50 = 69000.0 nM 4.16
CHEMBL167979 IC50 = 1260000.0 nM -
CHEMBL167967 IC50 = 120000.0 nM -
CHEMBL441492 IC50 = 1200000.0 nM -
CHEMBL165809 IC50 = 143000.0 nM -
CHEMBL166791 IC50 = 320000.0 nM -
CHEMBL166811 IC50 = 1000000.0 nM -
CHEMBL354158 IC50 = 900000.0 nM -
CHEMBL553877 IC50 > 2500000.0 nM -
CHEMBL433527 IC50 = 480000.0 nM -
CHEMBL167408 IC50 = 190000.0 nM -
CHEMBL168464 IC50 = 1390000.0 nM -
CHEMBL166723 IC50 = 890000.0 nM -
CHEMBL353761 IC50 = 217000.0 nM -
CHEMBL19486 IC50 = 170000.0 nM -
CHEMBL354726 IC50 = 120000.0 nM -
CHEMBL354866 IC50 = 135000.0 nM -
CHEMBL168580 IC50 = 480000.0 nM -
CHEMBL168468 IC50 = 260000.0 nM -
CHEMBL354506 IC50 = 230000.0 nM -