Assay Detail
Binding
CHEMBL642867
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Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes
45
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.82 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73461 | IRINDALONE | 2.0 | 1 | 8.59 |
| CHEMBL1744123 | — | — | 1 | 7.62 |
| CHEMBL422067 | — | — | 1 | 7.58 |
| CHEMBL92896 | — | — | 1 | 7.52 |
| CHEMBL1788129 | — | — | 1 | 7.42 |
| CHEMBL1744113 | — | — | 1 | 7.39 |
| CHEMBL1204307 | — | — | 1 | 7.37 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.33 |
| CHEMBL1744107 | — | — | 1 | 7.28 |
| CHEMBL1744108 | — | — | 1 | 7.22 |
| CHEMBL1744114 | — | — | 1 | 7.21 |
| CHEMBL1744124 | — | — | 1 | 7.18 |
| CHEMBL2112372 | — | — | 2 | 7.17 |
| CHEMBL1744125 | — | — | 1 | 7.14 |
| CHEMBL1204306 | — | — | 2 | 7.14 |
| CHEMBL1744126 | — | — | 1 | 7.11 |
| CHEMBL1744112 | — | — | 1 | 6.96 |
| CHEMBL1744111 | — | — | 1 | 6.96 |
| CHEMBL1744115 | — | — | 1 | 6.92 |
| CHEMBL2447981 | — | — | 1 | 6.85 |
| CHEMBL320684 | — | — | 1 | 6.82 |
| CHEMBL1788128 | — | — | 1 | 6.77 |
| CHEMBL1744105 | — | — | 1 | 6.75 |
| CHEMBL96571 | — | — | 1 | 6.70 |
| CHEMBL1744121 | — | — | 3 | 6.68 |
| CHEMBL2111567 | — | — | 3 | 6.68 |
| CHEMBL1744120 | — | — | 1 | 6.62 |
| CHEMBL92408 | — | — | 1 | 6.60 |
| CHEMBL1744122 | — | — | 1 | 6.57 |
| CHEMBL1744118 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73461 | IRINDALONE | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1744123 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL422067 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL92896 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1788129 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1744113 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1204307 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1744107 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1744108 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1744114 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1744124 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2112372 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1204306 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1744125 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1744126 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1744111 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1744112 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1744115 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2447981 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL320684 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1788128 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1744105 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL96571 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2111567 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1744121 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2111567 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1744120 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL92408 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1744121 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1744122 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1744118 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1744127 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1744121 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2112372 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2447982 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1744117 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1744116 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1744119 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1744109 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1744110 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1744128 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1744106 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1204306 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2111567 | — | IC50 | = | 2500.0 | nM | 5.60 |