Assay Detail
Binding
CHEMBL642883
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In vitro inhibitory concentration against acetylcholinesterase of human erythrocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.91 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539051 | — | — | 1 | 7.42 |
| CHEMBL541344 | — | — | 1 | 7.29 |
| CHEMBL542497 | — | — | 1 | 7.11 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.69 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 6.58 |
| CHEMBL539072 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539051 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL541344 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL542497 | — | IC50 | = | 76.9 | nM | 7.11 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL539072 | — | IC50 | = | 436.0 | nM | 6.36 |