Assay Detail
Binding
CHEMBL642955
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In vitro inhibition of rabbit lens aldose reductase.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.74 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.17 |
| CHEMBL77692 | — | — | 1 | 6.68 |
| CHEMBL312109 | OXEPINAC | 2.0 | 1 | 6.48 |
| CHEMBL75245 | TIOPINAC | 2.0 | 1 | 6.16 |
| CHEMBL77283 | — | — | 1 | 6.12 |
| CHEMBL311679 | — | — | 1 | 6.11 |
| CHEMBL538917 | — | — | 1 | 6.08 |
| CHEMBL77601 | — | — | 1 | 6.00 |
| CHEMBL75630 | — | — | 1 | 5.57 |
| CHEMBL306710 | — | — | 1 | 5.51 |
| CHEMBL74436 | — | — | 1 | 5.30 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.22 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 4.00 |
| CHEMBL75244 | — | — | 1 | 4.00 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | - |
| CHEMBL432929 | — | — | 1 | - |
| CHEMBL312290 | — | — | 1 | - |
| CHEMBL74025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL77692 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL312109 | OXEPINAC | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL75245 | TIOPINAC | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL77283 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL311679 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL538917 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL77601 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL75630 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL306710 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL74436 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL23588 | FLUFENAMIC ACID | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL75244 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL424 | SALICYLIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL571 | KETOPROFEN | IC50 | = | 180000.0 | nM | - |
| CHEMBL432929 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL312290 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL74025 | — | IC50 | = | 160000.0 | nM | - |