Assay Detail
Binding
CHEMBL642967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of crude aldose reductase of rat lens
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 8.00 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.77 |
| CHEMBL62197 | — | — | 1 | 6.35 |
| CHEMBL305164 | — | — | 1 | 6.04 |
| CHEMBL63055 | ALRESTATIN | 2.0 | 1 | 5.82 |
| CHEMBL291659 | — | — | 1 | 5.62 |
| CHEMBL64312 | — | — | 1 | 5.48 |
| CHEMBL64455 | — | — | 1 | 5.22 |
| CHEMBL428495 | — | — | 1 | 4.50 |
| CHEMBL64552 | — | — | 1 | 4.48 |
| CHEMBL62329 | — | — | 1 | - |
| CHEMBL59766 | — | — | 1 | - |
| CHEMBL292547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL266497 | SORBINIL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL62197 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL305164 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL63055 | ALRESTATIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL291659 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL64312 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL64455 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL428495 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL64552 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL62329 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL59766 | — | IC50 | = | 590000.0 | nM | - |
| CHEMBL292547 | — | IC50 | = | 470000.0 | nM | - |