Assay Detail
Binding
CHEMBL642969
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Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.40 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12253 | — | — | 1 | 6.82 |
| CHEMBL273984 | — | — | 1 | 6.58 |
| CHEMBL268282 | — | — | 1 | 6.43 |
| CHEMBL276641 | — | — | 1 | 5.68 |
| CHEMBL12252 | 5,7-DIHYDROXY-4-METHYLCOUMARIN | — | 1 | 4.77 |
| CHEMBL428495 | — | — | 1 | 4.50 |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | 4.21 |
| CHEMBL11692 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12253 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL273984 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL268282 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL276641 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL12252 | 5,7-DIHYDROXY-4-METHYLCOUMARIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL428495 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL12208 | HYMECROMONE | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL11692 | — | IC50 | = | 61000.0 | nM | 4.21 |