Assay Detail
Binding
CHEMBL642970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.01 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.77 |
| CHEMBL12655 | — | — | 1 | 7.70 |
| CHEMBL268279 | — | — | 1 | 6.85 |
| CHEMBL12281 | — | — | 1 | 6.62 |
| CHEMBL268492 | — | — | 1 | 6.25 |
| CHEMBL274190 | — | — | 1 | 6.22 |
| CHEMBL12580 | — | — | 1 | 5.36 |
| CHEMBL276618 | 4-METHYLDAPHNETIN | — | 1 | 5.00 |
| CHEMBL12241 | — | — | 1 | 5.00 |
| CHEMBL12567 | — | — | 1 | 4.96 |
| CHEMBL275000 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL12655 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL268279 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL12281 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL268492 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL274190 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL12580 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL276618 | 4-METHYLDAPHNETIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12241 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12567 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL275000 | — | IC50 | = | 38000.0 | nM | 4.42 |