Assay Detail
Binding
CHEMBL642971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lens
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.97 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.70 |
| CHEMBL156333 | — | — | 1 | 4.47 |
| CHEMBL346956 | — | — | 1 | 4.30 |
| CHEMBL156389 | — | — | 1 | 4.24 |
| CHEMBL158893 | — | — | 1 | 4.12 |
| CHEMBL422692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL156333 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL346956 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL156389 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL158893 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL422692 | — | IC50 | = | 214000.0 | nM | - |