Assay Detail
Binding
CHEMBL642977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against partially purified rat lens Aldose reductase at a dose of 5e-7M
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.32 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.68 |
| CHEMBL269550 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL269550 | — | IC50 | = | 110.0 | nM | 6.96 |