Assay Detail
Binding
CHEMBL642987
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Binding affinity towards adenosine A1 receptor in rat whole brain membranes using N6-[3H]cyclohexyladenosine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.06 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.34 |
| CHEMBL268071 | — | — | 1 | 8.14 |
| CHEMBL16687 | CGS-15943 | — | 1 | 7.69 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL268071 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL16687 | CGS-15943 | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 86.0 | nM | 7.07 |