Assay Detail
Functional
CHEMBL643014
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Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidine
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.91 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416072 | — | — | 1 | 9.07 |
| CHEMBL290853 | — | — | 1 | 8.80 |
| CHEMBL41111 | — | — | 1 | 8.16 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.91 |
| CHEMBL43401 | — | — | 1 | 7.81 |
| CHEMBL41756 | — | — | 1 | 7.48 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 6.14 |
| CHEMBL41103 | — | — | 1 | - |
| CHEMBL43138 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416072 | — | Kd | = | 0.8511 | nM | 9.07 |
| CHEMBL290853 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL41111 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL43401 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL41756 | — | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL2 | PRAZOSIN | Kd | = | 724.44 | nM | 6.14 |
| CHEMBL41103 | — | Kd | < | 1000.0 | nM | - |
| CHEMBL43138 | — | Kd | > | 1000.0 | nM | - |