Assay Detail
Binding
CHEMBL643123
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Affinity to Adenosine A3 receptor of rat testis membrane using [3H](R)-PIA with 150 nM DPCPX
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.09 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | — | 1 | 7.28 |
| CHEMBL400189 | — | — | 1 | 6.68 |
| CHEMBL420705 | (S)-PIA | — | 1 | 6.62 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.58 |
| CHEMBL3143982 | — | — | 1 | 6.17 |
| CHEMBL2113388 | — | — | 1 | 5.97 |
| CHEMBL3143985 | — | — | 1 | 5.29 |
| CHEMBL3143983 | — | — | 1 | 5.21 |
| CHEMBL603977 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL400189 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL420705 | (S)-PIA | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3143982 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL2113388 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL3143985 | — | Ki | = | 5170.0 | nM | 5.29 |
| CHEMBL3143983 | — | Ki | = | 6160.0 | nM | 5.21 |
| CHEMBL603977 | — | Ki | = | 10000.0 | nM | 5.00 |