Assay Detail
Binding
CHEMBL643128
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Binding affinity of adenosine derivative for endogenous rat Adenosine A3 receptor expressed on CHO cell
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.14 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.05 |
| CHEMBL342873 | — | — | 1 | 8.89 |
| CHEMBL307199 | — | — | 1 | 8.80 |
| CHEMBL344187 | — | — | 1 | 7.31 |
| CHEMBL111545 | — | — | 1 | 6.63 |
| CHEMBL88147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL342873 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL307199 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL344187 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL111545 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL88147 | — | Ki | > | 10.0 | nM | - |