Assay Detail
Binding
CHEMBL643129
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Binding affinity of adenosine derivative for endogenous rat Adenosine A3 receptor of RBL-2H3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.71 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307199 | — | — | 1 | 8.57 |
| CHEMBL342873 | — | — | 1 | 8.54 |
| CHEMBL344187 | — | — | 1 | 7.29 |
| CHEMBL111545 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307199 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL342873 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL344187 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL111545 | — | Ki | = | 357.0 | nM | 6.45 |