Assay Detail
Binding
CHEMBL643131
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Binding affinity for rat A3-adenosine receptor expressed in chinese hamster ovarian cells (assayed by the displacement of specific [125I]-N6-(4-amino-3-iodobenzyl)-adenosine-5''-N-methyluronamide)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovarian |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.63 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 8.96 |
| CHEMBL133566 | — | — | 1 | 8.90 |
| CHEMBL2113620 | — | — | 1 | 8.72 |
| CHEMBL610426 | — | — | 1 | 8.55 |
| CHEMBL1256785 | — | — | 1 | 8.00 |
| CHEMBL609642 | — | — | 1 | 7.92 |
| CHEMBL609245 | — | — | 1 | 7.85 |
| CHEMBL609923 | — | — | 1 | 7.77 |
| CHEMBL2113639 | — | — | 1 | 7.75 |
| CHEMBL610143 | — | — | 1 | 7.72 |
| CHEMBL609830 | — | — | 1 | 7.55 |
| CHEMBL608762 | — | — | 1 | 7.51 |
| CHEMBL610996 | — | — | 1 | 7.38 |
| CHEMBL608653 | — | — | 1 | 6.31 |
| CHEMBL610429 | — | — | 1 | 5.88 |
| CHEMBL608652 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL133566 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL2113620 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL610426 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1256785 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL609642 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL609245 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL609923 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2113639 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL610143 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL609830 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL608762 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL610996 | — | Ki | = | 41.4 | nM | 7.38 |
| CHEMBL608653 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL610429 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL608652 | — | Ki | = | 4500.0 | nM | 5.35 |