Assay Detail
Binding
CHEMBL643232
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In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.90 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317912 | — | — | 1 | 8.06 |
| CHEMBL327116 | — | — | 1 | 7.64 |
| CHEMBL109783 | — | — | 1 | 7.48 |
| CHEMBL108804 | — | — | 1 | 7.35 |
| CHEMBL323402 | — | — | 1 | 7.14 |
| CHEMBL111463 | — | — | 1 | 7.07 |
| CHEMBL111771 | — | — | 1 | 7.01 |
| CHEMBL111554 | — | — | 1 | 6.98 |
| CHEMBL111496 | — | — | 1 | 6.88 |
| CHEMBL326702 | — | — | 1 | 6.77 |
| CHEMBL61006 | PHENYLPROPANOLAMINE | 4.0 | 1 | 6.56 |
| CHEMBL110751 | — | — | 1 | 6.51 |
| CHEMBL109848 | — | — | 1 | 6.26 |
| CHEMBL321644 | — | — | 1 | 6.02 |
| CHEMBL1076 | DESGLYMIDODRINE | -1.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317912 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL327116 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL109783 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL108804 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL323402 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL111463 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL111771 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL111554 | — | Ki | = | 104.71 | nM | 6.98 |
| CHEMBL111496 | — | Ki | = | 131.83 | nM | 6.88 |
| CHEMBL326702 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL61006 | PHENYLPROPANOLAMINE | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL110751 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL109848 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL321644 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL1076 | DESGLYMIDODRINE | Ki | = | 1445.44 | nM | 5.84 |