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Compound Detail

CHEMBL110751

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O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F

Basic Information

ChEMBL ID CHEMBL110751
Phase Preclinical
Structure Type MOL
InChI Key WNIQCRWLPXLGQD-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

309.3
MW (Da)
3.38
ALogP
2
HBA
2
HBD
57.8
PSA (Ų)
0.89
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H14F3N3O
MW 309.29
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.65

Activity Summary

Ki 4 meas. best 6.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL319
Ki 6.78 6.78 166.0 1
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 6.51 6.51 309.0 1
Alpha-2B adrenergic receptor
CHEMBL266
Ki 6.18 6.18 660.7 1
Alpha-1D adrenergic receptor
CHEMBL326
Ki 5.48 5.48 3311.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15163201 10.1021/jm030551a Alpha-1A adrenergic receptor 3
15163201 10.1021/jm030551a Alpha-1B adrenergic receptor 3
15163201 10.1021/jm030551a Alpha-2A adrenergic receptor 3
15163201 10.1021/jm030551a Unchecked 3
15163201 10.1021/jm030551a Canis familiaris 3
15163201 10.1021/jm030551a Alpha-1D adrenergic receptor 1
15163201 10.1021/jm030551a Alpha adrenergic receptor 1A and 1B 1
15163201 10.1021/jm030551a Alpha adrenergic receptor 1A and 1D 1
15163201 10.1021/jm030551a Alpha-2B adrenergic receptor 1

Data from ChEMBL 36 via Core Engine