Assay Detail
Binding
CHEMBL857772
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In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.57 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317912 | — | — | 1 | 8.42 |
| CHEMBL327116 | — | — | 1 | 7.65 |
| CHEMBL108804 | — | — | 1 | 7.32 |
| CHEMBL323402 | — | — | 1 | 7.31 |
| CHEMBL111771 | — | — | 1 | 6.73 |
| CHEMBL109783 | — | — | 1 | 6.61 |
| CHEMBL61006 | PHENYLPROPANOLAMINE | 4.0 | 1 | 6.58 |
| CHEMBL110751 | — | — | 1 | 6.18 |
| CHEMBL111554 | — | — | 1 | 6.17 |
| CHEMBL111463 | — | — | 1 | 6.04 |
| CHEMBL326702 | — | — | 1 | 6.01 |
| CHEMBL111496 | — | — | 1 | 5.77 |
| CHEMBL1076 | DESGLYMIDODRINE | -1.0 | 1 | 5.73 |
| CHEMBL109848 | — | — | 1 | 5.52 |
| CHEMBL321644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317912 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL327116 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL108804 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL323402 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL111771 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL109783 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL61006 | PHENYLPROPANOLAMINE | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL110751 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL111554 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL111463 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL326702 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL111496 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL1076 | DESGLYMIDODRINE | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL109848 | — | Ki | = | 3019.95 | nM | 5.52 |
| CHEMBL321644 | — | Ki | < | 10000.0 | nM | - |