Assay Detail
Binding
CHEMBL643367
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Maximal NECA stimulation of adenylate cyclase via adenosine A2 receptor in human platelet membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.66 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410873 | — | — | 1 | 6.98 |
| CHEMBL2113510 | — | — | 1 | 6.90 |
| CHEMBL319387 | — | — | 1 | 6.89 |
| CHEMBL2113507 | — | — | 1 | 6.38 |
| CHEMBL2113496 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410873 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2113510 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL319387 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL2113507 | — | EC50 | = | 414.0 | nM | 6.38 |
| CHEMBL2113496 | — | EC50 | = | 681.0 | nM | 6.17 |