Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL643368

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Stimulation of adenylate cyclase activity in human platelet membrane at A2 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094257)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
Cristalli G, Franchetti P, Grifantini M, Vittori S, Klotz KN, Lohse MJ.
J Med Chem (1988) 31 : 1179 -1183
PubMed 3373486 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.30 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464859 NECA 1 6.58
CHEMBL139000 (R)-PIA 1 6.02
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 5.66
CHEMBL2113396 1 5.55
CHEMBL605008 1 5.46
CHEMBL2113391 1 5.32
CHEMBL606016 1 5.18
CHEMBL115824 1 4.75
CHEMBL2113387 1 4.70
CHEMBL2113389 1 4.58
CHEMBL2113390 1 4.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464859 NECA EC50 = 260.0 nM 6.58
CHEMBL139000 (R)-PIA EC50 = 950.0 nM 6.02
CHEMBL68738 N6-CYCLOPENTYLADENOSINE EC50 = 2200.0 nM 5.66
CHEMBL2113396 EC50 = 2800.0 nM 5.55
CHEMBL605008 EC50 = 3500.0 nM 5.46
CHEMBL2113391 EC50 = 4800.0 nM 5.32
CHEMBL606016 EC50 = 6600.0 nM 5.18
CHEMBL115824 EC50 = 18000.0 nM 4.75
CHEMBL2113387 EC50 = 20000.0 nM 4.70
CHEMBL2113389 EC50 = 26000.0 nM 4.58
CHEMBL2113390 EC50 = 28000.0 nM 4.55