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Assay Detail

CHEMBL643386

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Binding
Inhibition of acetylcholinesterase activity
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
Cardozo MG, Kawai T, Iimura Y, Sugimoto H, Yamanishi Y, Hopfinger AJ.
J Med Chem (1992) 35 : 590 -601
PubMed 1738152 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 7.31 9.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL155945 1 9.09
CHEMBL345847 1 9.05
CHEMBL263322 1 8.82
CHEMBL155746 1 8.52
CHEMBL158252 1 8.38
CHEMBL153865 1 8.28
CHEMBL158232 1 8.28
CHEMBL345905 1 8.11
CHEMBL156874 1 8.08
CHEMBL345241 1 8.05
CHEMBL158174 1 8.00
CHEMBL156157 1 7.03
CHEMBL347354 1 6.80
CHEMBL343237 1 6.75
CHEMBL155121 1 6.66
CHEMBL156763 1 6.32
CHEMBL157017 1 5.92
CHEMBL155128 1 5.54
CHEMBL348318 1 5.48
CHEMBL157410 1 5.36
CHEMBL155768 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL155945 IC50 = 0.82 nM 9.09
CHEMBL345847 IC50 = 0.9 nM 9.05
CHEMBL263322 IC50 = 1.5 nM 8.82
CHEMBL155746 IC50 = 3.0 nM 8.52
CHEMBL158252 IC50 = 4.2 nM 8.38
CHEMBL153865 IC50 = 5.3 nM 8.28
CHEMBL158232 IC50 = 5.3 nM 8.28
CHEMBL345905 IC50 = 7.7 nM 8.11
CHEMBL156874 IC50 = 8.4 nM 8.08
CHEMBL345241 IC50 = 8.9 nM 8.05
CHEMBL158174 IC50 = 10.0 nM 8.00
CHEMBL156157 IC50 = 94.0 nM 7.03
CHEMBL347354 IC50 = 160.0 nM 6.80
CHEMBL343237 IC50 = 180.0 nM 6.75
CHEMBL155121 IC50 = 220.0 nM 6.66
CHEMBL156763 IC50 = 480.0 nM 6.32
CHEMBL157017 IC50 = 1200.0 nM 5.92
CHEMBL155128 IC50 = 2900.0 nM 5.54
CHEMBL348318 IC50 = 3300.0 nM 5.48
CHEMBL157410 IC50 = 4400.0 nM 5.36
CHEMBL155768 IC50 = 10000.0 nM 5.00