Assay Detail
Binding
CHEMBL643390
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Binding affinity towards adenosine A1 receptor using N6-[3H]cyclohexyladenosine in guinea pig forebrain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.36 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | 3.0 | 1 | 8.89 |
| CHEMBL84363 | — | — | 1 | 8.52 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.19 |
| CHEMBL84545 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL84363 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL84545 | — | Ki | = | 15.0 | nM | 7.82 |